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Kids, Antibiotics and Kidney Stones

Kids, Antibiotics and Kidney Stones

A study published Thursday in the Journal of the American Society of Nephrology found that taking any of five types of oral antibiotics was associated with a significantly higher risk of developing kidney stones - mineral and salt deposits that form in the kidneys and must be passed through the urinary tract. Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

"For some medications, the risk was about 50 percent increase for other medication it was about a two times greater increase, so there was a lot of variation depending on the antibiotic class", said Dr. Gregory Tasian, who led the research at Children's Hospital of Philadelphia.

In addition to their CHOP positions, Tasian, Denburg and Gerber are members of the Center for Clinical Epidemiology and Biostatistics (CCEB) in the Perelman School of Medicine at the University of Pennsylvania.

Kidney stones are not only painful, they also increase the risk for fragile bones, hypertension and heart disease.

Tasian anxious that this does not suggest individuals must prevent prescription antibiotics when they're really required.

"Antibiotics have saved millions of lives and are needed to prevent death and serious harm from infections", he said. "The advantages surpass the prospective damages".

And antibiotic prescriptions are increasingly common.

One kidney expert agreed that the proper use of the drugs is a balancing act.

Over the past 30 years, the overall prevalence of kidney stones has risen by 70pc, particularly among young women and adolescents, despite it being previously rare in the latter.

It is still unknown why kidney stones are on a hike these days but according to the study, consuming antibiotics certainly play a major role when it comes to prescribing them to children more than that of adults.

Professionals are uncertain regarding why. Disruptions in the intestinal and urinary microbiome have been linked to the occurrence of kidney stones, but no previous studies revealed an association between antibiotic usage and stones.

Results Exposure to any of five different antibiotic classes 3-12 months before index date was associated with nephrolithiasis.

Tasian and colleagues are continuing to investigate the microbiomes of children and adolescents with kidney stones in a single-center study at CHOP.

Now, that the link has been established between antibiotics and stones. They narrowed the sample to nearly 26,000 patients diagnosed with kidney stones, and a control group of almost 260,000 people without kidney stones. No risk was observed among seven other classes of oral antibiotics.

" At this time, we do not have any ways to restrict the threat connected with prescription antibiotics", Tasian stated.

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